Publications and Posters

    • Publications from INSPIRED Partners acknowledging the RISE funding (734749)
  1. Lhomond S., Avril T., Dejeans N., Voutetakis K., Doultsinos D., McMahon M., Pineau R., Obacz J., Papadodima O., Jouan F., Bourien H., Logotheti M., Jégou G., Pallares‐Lupon N., Schmit K., Le Reste P., Etcheverry A., Mosser J., Barroso K., Vauléon E., Maurel M., Samali A.,  Patterson J., Pluquet O., Hetz C., Quillien V, Chatziioannou A Chevet E. (2018) Dual IRE1 RNase functions dictate glioblastoma development. EMBO Molecular Medicine e7929 (Note 5 out of the 6 INSPIRED partners contributed to the research described in this publication)
  2. Cabral-Miranda F. and Hetz C. (2017). ER stress in neurodegenerative disease: a causal relationship? Endoplasmic Reticulum Stress in Diseases. 4:11-26.
  3. Carreras-Sureda A., Pihán P., and Hetz C. (2017). The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics. Frontiers Oncology. 3:55
  4. Duran-Aniotz C., Cornejo V., Espinoza S., Ardiles A., Medinas D., Salazar C., Foley A., Gajardo I., Thielen P., Iwawaki T., Scheper W., Soto C., Palacios A., Hoozemans J., and Hetz C. (2017). IRE1 signalling exacerbates Alzheimer’s disease pathogenesis. Acta Neuropathol. doi: 10.1007/s00401-017-1694-x
  5. Medinas D., Gonzalez J., Falcon P., and Hetz C. (2017). Fine-tuning the ER stress signal transducers to treat amyotrophic lateral sclerosis.Frontiers Mol Neurosci. 10: 1-8.
  6. Mercado G., and Hetz C. (2017). Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts. Brain. 140:1544-1547. Scientific commentary.
  7. Obacz , Avril T., Le Reste P., Urra H., Quillien V.,Hetz C. and Chevet E. (2017). Endoplasmic Reticulum proteostasis in glioblastoma- from molecular mechanisms to therapeutic perspectives. Science Signaling. 10(470).
  8. Pihán P., Carreras-Sureda A. and Hetz C. (2017). BCL-2 family: Integrating stress responses at the ER to control cell demise. Cell Death Diff. doi: 10.1038/cdd.2017.82
  9. Hetz C. and Papa F. (2017).  The unfolded protein response and cell fate control. Molecular Cell 69, January 18, 2018
  10. Sepulveda D., Rojas-Rivera D., Rodriguez D., Groenendyk J., Köhler A., Lebeaupin C., Ito S., Urra H., Carreras-Sureda A., Vasseur-Cognet M., Chevet E., Campos G., Godoy P., Vaisar T., Bailly-Maitre B., Nagata K., Michalak M., Sierralta J., and Hetz C.. (2018) Interactome screening identifies a novel function of the collagen chaperon Hsp47 as an adjustor of the unfolded protein response (UPR) transducer IRE1α. Mol Cell. 69:238-252. *# (Cover illustration)
  11. Matamala JM., Arias-Carrasco R., Sanchez C., Uhrig M., Bargsted L., Matus S., Maracaja-Coutinho V., Abarzua S., van Zundert B., Verdugo R., Manque P., Hetz C. (2018). Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Neurobiol. Aging. In press. *#
  12. Mercado G., Castillo V., Soto P., López N., Axten J., Sardi P., Hoozemans J. and Hetz C. (2018). Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson’s disease. Neurobiol. Dis.. pii: S0969-9961(18)30004-4. *
  13. Park K., Kim G., Morales R., Moda F., Moreno-Gonzalez I., Concha-Marambio L., Lee A.S., Hetz C., and Soto C. (2017). The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo. Scientific Rep. 7:44723*
  14. González A., Muñoz V., Cavieres V., Bustamante H., Cornejo V., Januário Y., González Y., Hetz C., daSilva L., Rojas-Fernández A., Hay R., Mardones G., and Burgos P. (2017). Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the Amyloid Precursor Protein via the MVB/lysosomal pathway. FASEB J. 31:2446-2459*#
  15. Castillo K., Valenzuela V., Oñate M., and Hetz C. (2017) A molecular reporter for monitoring autophagy flux in the nervous system. Methods Enzymol. 588:109-131 *#
  16. Bargsted L., Medinas D., Martínez F., Rozas P., Muñoz N., Nassif M., Jerez C., Catenaccio A., Court, F. Hetz C., and Matus C. (2017). Disulfide cross-linked multimers of TDP-43 and spinal motor neuron loss in a TDP-43A315T ALS/FTD mouse model. Scientific Reports. 7:14266
  17. Hery Urra, Daniel R. Henriquez, José Cánovas, David Villarroel-Campos, Amado Carreras-Sureda, Eduardo Pulgar, Emiliano Molina, Younis M. Hazari, Celia M. Limia, Sebastián Alvarez-Rojas, Ricardo Figueroa, Rene L. Vidal, Diego A. Rodriguez, Claudia A. Rivera, Felipe A. Court, Andrés Couve, Ling Qi, Eric Chevet, Ryoko Akai, Takao Iwawaki, Miguel L. Concha, Álvaro Glavic, Christian Gonzalez-Billault & Claudio Hetz (2018) IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A. Nature Cell Biology