Fantastic work by Inspired partner Claudio Hetz and co-author Eric Chevet showing an unanticipated role for IRE1α in cell migration.
In this study they showed that IRE1α controls actin cytoskeleton dynamics and affects cell migration upstream of filamin A. Their demonstrated that IRE1 interacts with Filamin A which is an actin crosslinking factor involved in cytoskeleton remodelling. IRE1 regulates cytoskeleton dynamics independent of its canonical role as a UPR mediator, serving instead as a scaffold that recruits and regulates filamin A. Targeting IRE1α expression in mice affected normal brain development, generating a phenotype resembling periventricular heterotopia, a disease linked to the loss of function of filamin A. IRE1α also modulated cell movement and cytoskeleton dynamics in fly and zebrafish models.
Their work unveils an unanticipated biological function of IRE1α in cell migration, whereby filamin A operates as an interphase between the UPR and the actin cytoskeleton. See doi.org/10.1038/s41556-018-0141-0
The INSPIRED Network had its mid-term review on 19th April. The EU Project Officer, the network partners and seconded staff traveled to Ireland for the review. Progress in each workpackage was presented and overall project progress was viewed to be very positive.
Well done to all the INSPIRED partners and seconded staff members!
INSPIRED partners, seconded staff and EU Project Officer at the INSPIRED mid-term review
INSPIRED Partners relaxing in Galway after the midterm review
A symposium on ER stress in Cancer and Neurodegeneration was held at NUI Galway, Ireland on 18th April 2018. The event formed part of the INSPIRED workshop/symposia series. There was an excellent line up of speakers and a lot of researchers with an interest in ER stress attended the symposium.
Alexis, an experienced researcher, currently on a 1 year secondment from Chile to Ireland celebrated his birthday recently.
Members of the Samali lab at NUI Galway tucked into some birthday cake with Alexis to mark the occassion! Knowledge of typical Irish and Chilean birthday cakes was exchanged…..